![]() ![]() To explain the difference in continuity, they established a Multiverse with the different versions of the heroes occupying different worlds. There was a revival in the late fifties and early sixties with the creation of newer more imaginative updates of characters like Green Lantern and The Flash, leading to DC's biggest characters forming the Justice League. Their massive early popularity was stunted by the invention of The Comics Code which nearly killed the industry, and many of the bowdlerised stories from this era are responsible for several negative stereotypes about the medium. Their introduction of the Justice Society of America during World War II was also the first real super-hero team book, using the cross-over to establish the first shared universe in comics history. The DC Universe is primarily responsible for establishing the concept of the super-hero in popular culture, with Batman, Superman and Wonder Woman as some of their oldest and most popular characters. This is mostly used as a vehicle for their extensive Super Hero mythos, although the nature of the universe allows for almost unlimited storytelling potential in many different genres. 2022.The DC Universe is the Shared Universe belonging to DC Comics, established in 1934 and now the oldest major comic book publishing company. The suggestion is made that detection of a FLT3/ITD should be included as a routine test at diagnosis and evaluated for therapeutic management.īottomly D, Long N, Schultz AR, Kurtz SE, Tognon CE, Johnson K, Abel M, Agarwal A, Avaylon S, Benton E, Blucher A, Borate U, Braun TP, Brown J, Bryant J, Burke R, Carlos A, Chang BH, Cho HJ, Christy S, Coblentz C, Cohen AM, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Dibb J, Eide CA, English I, Hagler S, Harrelson H, Henson R, Ho H, Joshi SK, Junio B, Kaempf A, Kosaka Y, Laderas T, Lawhead M, Lee H, Leonard JT, Lin C, Lind EF, Liu SQ, Lo P, Loriaux MM, Luty S, Maxson JE, Macey T, Martinez J, Minnier J, Monteblanco A, Mori M, Morrow Q, Nelson D, Ramsdill J, Rofelty A, Rogers A, Romine KA, Ryabinin P, Saultz JN, Sampson DA, Savage SL, Schuff R, Searles R, Smith RL, Spurgeon SE, Sweeney T, Swords RT, Thapa A, Thiel-Klare K, Traer E, Wagner J, Wilmot B, Wolf J, Wu G, Yates A, Zhang H, Cogle CR, Collins RH, Deininger MW, Hourigan CS, Jordan CT, Lin TL, Martinez ME, Pallapati RR, Pollyea DA, Pomicter AD, Watts JM, Weir SJ, Druker BJ, McWeeney SK, Tyner JW. Biallelic disease or partial/complete loss of wild-type alleles was present in 10% of FLT3/ITD(+) patients. More than one mutation was detected in 23% of FLT3/ITD(+) patients and was associated with worse OS (P =.04) and EFS (P =.07). There was no evidence that the relative effect of a FLT3/ITD differed between the cytogenetic risk groups. In multivariate analysis, presence of a mutation was the most significant prognostic factor predicting RR and DFS (P <.0001) and was still significant for OS (P =.009) and EFS (P =.002). It had a borderline association with a lower complete remission rate (P =.05) and a higher induction death rate (P =.04), and was associated with increased relapse risk (RR), adverse disease-free survival (DFS), event-free survival (EFS), and overall survival (OS) (P <.001 for all). An FLT3/ITD mutation was present in 27% of the patients and was associated with leukocytosis and a high percentage of bone marrow blast cells (P <.001 for both). This study evaluated the impact of a FLT3/ITD mutation on outcome in 854 patients, mostly 60 years of age or younger, treated in the United Kingdom Medical Research Council (MRC) AML trials. ![]() Recent studies have indicated that an internal tandem duplication (ITD) in the FLT3 gene may adversely affect clinical outcome. In acute myeloid leukemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse.
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